Estradiol (E2)
Estradiol, the principal estrogen found in a woman's body during the reproductive years, is produced by the ovaries. Estradiol may be very effective for the symptomatic relief of hot flashes, genitourinary symptoms, osteoporosis prophylaxis, psychological well-being and reduction of coronary artery disease.
Because it is much more potent than estriol, it might be more effective for symptomatic relief than estriol. When estradiol is replaced using a parenteral (sublingual, pellet implant, percutaneous, or transdermal) route, it may not be subject to first-pass metabolism by the liver, and therefore does not produce high levels of estrone. Using these routes of administration, a woman might be able to mimic the physiologic release of estradiol from the ovaries, thus receiving natural hormone replacement. |
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